PepTalk 2023

MOBILion Technical Talk:

Tackling the Peptide Isomer Impurity Challenge with High-Resolution Ion Mobility Mass Spectrometry

January 16, 2023 | 12:15pm | Heidi Vitrac PhD

The pace of therapeutic peptide drug development has significantly increased over the last decade. To improve peptide therapeutic biological function and pharmacokinetics, several strategies have been employed, including amino acid substitution, incorporation of unnatural amino acids, amino acid modifications and cyclization. High-resolution ion mobility mass spectrometry improves therapeutic peptide impurity analysis with its ability to resolve complex mixtures of D&L amino acid isomers, deamidations and positional isomers in the gas phase.

â€