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Peptide Characterization

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Unravel the Complexity of Peptide Analysis

Changes in peptides can effect the safety and performance of therapeutics, making structural analysis a critical step in drug development.

The Problem

The Problem

Scientists need the ability to identify and measure peptide modifications, structure, and impurities more definitively.

With liquid chromatography-mass spectrometry (LC-MS), lack of resolution lets some deamidation and isomerization events go undetected. Where the resolution is high enough, quantitative analysis can take over an hour.

Our Solution

Our Solution

Combining the MOBIE® platform’s high-resolution ion mobility mass spectrometry (HRIM-MS) with liquid chromatography more accurately separates and identifies impurities and post-translational modifications (PTMs) and reduces run times and costs.

Benefits of HRIM

Benefits of HRIM

  • Identification of mass-neutral PTMs difficult to monitor by LC-MS alone
  • Increased throughput for separation, detection, and quantitation of key analytes
  • Detection of degradation products during manufacturing
  • Reduced dependency on liquid chromatography
Peptide Characterization

Reduce LC run time (left) while maintaining high-resolution separation in the ion mobility dimension (right). Here, the ion mobility data is identical, independent of the LC gradient used.

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