What We Do / Workflows
Peptide Characterization
Unravel the Complexity of Peptide Analysis
Changes in peptides can effect the safety and performance of therapeutics, making structural analysis a critical step in drug development.
The Problem
Scientists need the ability to identify and measure peptide modifications, structure, and impurities more definitively.
With liquid chromatography-mass spectrometry (LC-MS), lack of resolution lets some deamidation and isomerization events go undetected. Where the resolution is high enough, quantitative analysis can take over an hour.
Our Solution
Combining the MOBIE® platform’s high-resolution ion mobility mass spectrometry (HRIM-MS) with liquid chromatography more accurately separates and identifies impurities and post-translational modifications (PTMs) and reduces run times and costs.
Benefits of HRIM
- Identification of mass-neutral PTMs difficult to monitor by LC-MS alone
- Increased throughput for separation, detection, and quantitation of key analytes
- Detection of degradation products during manufacturing
- Reduced dependency on liquid chromatography
Reduce LC run time (left) while maintaining high-resolution separation in the ion mobility dimension (right). Here, the ion mobility data is identical, independent of the LC gradient used.
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