Perform Glycan Analysis with Confidence
Because of its direct impact on product safety and efficacy, protein glycosylation is a critical quality attribute for biotherapeutics. A major challenge in characterization is the high heterogeneity of these glycans.
Confident identification is needed to reproducibly identify and quantify glycan isomers to assess safety, efficacy, and immunogenicity of proposed drug products and for biological research, yet current methods fall short. Existing liquid chromatography (LC) techniques are slow and often can't distinguish key isomers, limiting how many samples can be processed.
High-resolution ion mobility helps you understand what you’re looking at. The MOBIE® platform resolves 10% more glycan species, 2x faster, than any other platform on the market, with the highest reproducibility and quantitative accuracy.
Benefits of HRIM
- Superior resolution, enabling separation of isoforms missed by liquid chromatography-mass spectrometry
- Improved throughput with 2-minute flow injection analysis
- Reduced LC run times
- Reduced dependence on separation by LC
- Enhanced sensitivity to detect low abundant isomers