Application Notes

Refining the Landscape of Drug Isomer Analysis with High-Resolution Ion Mobility

Author(s)

Benjamin Blakely

Abstract

Emerging high-resolution ion mobility (HRIM) instrumentation, such as the MOBILion MOBIE® system, is refining the landscape of drug isomer analysis, enabling the differentiation of structural (constitutional) isomers, cis/trans isomers, and in special cases even stereoisomers across a wide mass and mobility range. Here, we showcase the IM-MS analysis of the epimeric corticosteroids dexamethasone and betamethasone. Importantly, these drugs exhibit the ability to self-associate into multimers (dimers and trimers) which can be observed on the MOBIE system as resolving their corresponding isomeric components.

Customer Intro

Problem

Solution

Summary

Abstract

The MOBIE® system is capable of accessing high-resolution IM (HRIM) resolving power across a wide mobility range, enabling the analysis of multimers across a broad mass and mobility range using HRIM.
MOBIE analysis enables the discovery of heterodimer and heterotrimer peaks in mixture data.

Results